Role of the cytochrome P450-soluble epoxide pathway in the regulation of lymphangiogenesis (A06)

• Subject Area: Anatomy and Physiology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 204083920

This project will address the hypothesis that activation of the cytochrome P450/soluble epoxide hydrolase (sEH) pathway affects lymphangiogenesis under physiological and pathophysiological conditions. A series of in vitro and in vivo models will be used to identify epoxide- and diol–dependent alterations in signalling and metabolism that contribute to lymphatic endothelial cell specification, lymphatic integrity, and lymphangiogenesis. The translational potential of interfering with this pathway to prevent the loss of lymphatic integrity after injury will also be determined.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1039: Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Ingrid Fleming, Ph.D.