The noncanonical function of 5-lipoxygenase as a regulator of gene expression (A02)

Subject Area Pharmacy
Term since 2013
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 204083920
 

Project Description

The noncanonical function of 5-lipoxygenase as transcriptional regulator of inflammatory and regenerative processes as well as the identification of the involved 5-LO isoforms will be addressed. The signalling mechanisms linked with the noncanonical 5-LO functions will be investigated using three representative genes (kynureninase, WNT rezeptor Frizzled 3 and the miRNA cluster miR-99b/let-7e/125a).
DFG Programme Collaborative Research Centres
Subproject of SFB 1039:  Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease
Applicant Institution Goethe-Universität Frankfurt am Main
Project Head Professor Dr. Dieter Steinhilber