Project Details
Projekt
Gnotobiology unit within the SPP 1656
Applicant
Professor Dr. André Bleich
Subject Area
Immunology
Gastroenterology
Parasitology and Biology of Tropical Infectious Disease Pathogens
Gastroenterology
Parasitology and Biology of Tropical Infectious Disease Pathogens
Term
from 2013 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 237393528
Axenic and defined colonized animals provide unique opportunities to model and study physiological and pathophysiological microbiome-host interactions. They can be utilized to investigate the “naive” mucosa as well as the impact of specific germs or microbial products on a host otherwise devoid of microorganisms. The Institute for Laboratory Animal Science and Central Animal Facility of the Hannover Medical School (Ztm) has a long tradition of gnotobiotic work, including generation and maintenance of germ-free models and their utilization in experimental settings. This expertise has been successfully incorporated in various collaborations and cooperative research projects, e.g., the SFB 621. The aim of this proposal is to make this techniques and experience available to members of the SPP 1656. Axenic and defined colonised animals will be accessible, models will be derived into germ-free state and maintained over defined periods of time, and collaborative gnotobiotic experiments can be conducted at Ztm. In addition, a network of gnotobiology units shall be established to best support the members of the SPP 1656. Thereby, this project is intended to contribute to unravel physiological mechanisms of colonization and development of immune responses as well as to identify determinants of the microbiome-host interplay that contribute to development of pathological conditions in a variety of disease models or resistance against pathogens.
DFG Programme
Priority Programmes
