Heisenberg Professorship in Hematology/Oncology "Immune-regulation and tumor immunology"

• Applicant: Professor Dr. Robert Zeiser
• Subject Area: Hematology, Oncology
• Term: from 2013 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 235287988

• Final Report Year: 2018

Final Report Abstract

No abstract available

Publications

• The NIrp3 inflammasome regulates acute graft-versus-host disease. Journal of Experimental Medicine, Vol. 210. 2013, Issue 10, pp. 1899–1910.
  Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber FC, Guarda G. Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer JC, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin SF, Gorka 0, Peschel C, Ruland J, ldzko M, Duyster J, Holler E, French LE, Poeck H, Contassot E Zeiser FL
  (See online at https://doi.org/10.1084/jem.20130084)
• Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance GvHD via tissue damage. Nature Medicine, Vol. 20. 2014, pp. 648–654.
  Schwab L, Goroney, L, S. Palaniyandi S, S. Gautam, A. Triantafyllopoulou, A. Mocsai, W. Reichardt, F.J. Karlsson, S.V. Radhakrishnan, K Hanke, A. Schmitt-Gräff, M. Freudenberg, F.D. von Loewenich, P. Wolf, F. Leonhardt, N. Baxan, D. Pfeifer, 0. Schmah, A. Schönle, S.F. Martin, R. Mertelsmann, J. Duyster, J. Finke, M. Plinz, P. Henneke, H. Häcker, Hildebrandt, G.C., Häcker G. Zeiser
  (See online at https://doi.org/10.1038/nm.3517)
• Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into allereactive T cells. Blood, Vol. 127. 2016, Issue 15 pp. 1930–1939.
  Schönle A, Hartl FA, Mentzel J, Nöltner T, Rauch KS, Prestipino A, Wohtfeil SA, Apostolova P, Hechinger AK, Melchinger W, Fehrenbach K, Guadamillas MC, Follo M, Prinz G, Ruess AK, Pfeifer D, del Pozo MA, Schmitt-Graeff A, Duyster J, Hippen KI, Blazar BR, Schachtrup K, Minguet S, Zeiser R.
  (See online at https://doi.org/10.1182/blood-2015-09-672428)
• Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy. The New England Journal of Medicine, Vol. 377. 2017, Issue 22, pp. 2167-2179.
  Zeiser R., Blazar B.
  (See online at https://dx.doi.org/10.1056/NEJMra1609337)
• MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation. Leukemia, Vol. 31. 2017, Issue 12, pp. 2732–2741.
  Stickel N., Hanke K., Marschner D., Prinz G., Köhler M., Melchinger W., Pfeifer D., Schmitt-Graeff A., Brummer T., Heine A., Brossart P. Wolf D., von Bubnoff N., Finke J., Duyster J., Ferrara J., Salzer U., Zeiser R.
  (See online at https://doi.org/10.1038/leu.2017.137)
• Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood, Vol. 131. 2018, Issue 16, pp. 1858–1869.
  Hülsdünker J., Ottmüller K.J., Neeff H.P., Koyama M., Gao Z., Thomas O.S., Follo M., Al-Ahmad A., Prinz G., Duquesne S., Dierbach H., Kirschnek S., Lämmermann T., Blaser M.J., Fife B.T., Blazar B.R., Beilhack A., Hill G.R., Häcker G., Zeiser R.
  (See online at https://doi.org/10.1182/blood-2017-10-812891)