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Proton-coupled conformational changes in photoreceptors (B06)

Subject Area Biophysics
Term since 2013
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 221545957
 
By combining structural biology methods, protein engineering, and vibrational spectroscopy, we aim at determining the structural basis and dynamics of the proton-dependent reaction steps in phytochromes. Specific objectives are to analyze (i) the differences in the protonation-dependent reaction mechanism along the Pr/Pfr and Pfr/Pr transformations of prototypical and bathy bacteriophytochromes, (ii) different proton-dependent mechanisms of photosensor activation in prokaryotic and eukaryotic phytochromes, and (iii) cause-effect relationships between movements of chromophore, protons, and protein building blocks.
DFG Programme Collaborative Research Centres
Applicant Institution Freie Universität Berlin
 
 

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