Project Details
Proton-coupled conformational changes in photoreceptors (B06)
Subject Area
Biophysics
Term
since 2013
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 221545957
By combining structural biology methods, protein engineering, and vibrational spectroscopy, we aim at determining the structural basis and dynamics of the proton-dependent reaction steps in phytochromes. Specific objectives are to analyze (i) the differences in the protonation-dependent reaction mechanism along the Pr/Pfr and Pfr/Pr transformations of prototypical and bathy bacteriophytochromes, (ii) different proton-dependent mechanisms of photosensor activation in prokaryotic and eukaryotic phytochromes, and (iii) cause-effect relationships between movements of chromophore, protons, and protein building blocks.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1078:
Protonation Dynamics in Protein Function
Applicant Institution
Freie Universität Berlin
Project Heads
Professor Dr. Peter Hildebrandt; Dr. Patrick Scheerer