Project Details
Projekt
Coordination of bacterial two component system signaling (P15)
Subject Area
Metabolism, Biochemistry and Genetics of Microorganisms
Term
from 2012 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 180879236
Project P15 (Hunke) analyzes the role of accessory proteins in coordinating bacterial two-component signaling (TCS) forming a microcompartment in the bacterial plasma membrane. The E. coli Cpx-TCS detects and responds to perturbations of the bacterial envelope and transmits signals within and between bacterial membranes. The group will (a) determine the molecular basis of the communication between CpxA receptor and the soluble CpxP (b) analyze how the Cpx-TCS system interacts with the outer membrane lipoprotein NlpE to allow signaling across two membranes, and (c) unravel how signaling is coordinated with transcription.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Osnabrück
Project Heads
Professor Dr. Michael Hensel; Professorin Dr. Sabine Hunke, until 6/2016; Dr. Katarzyna Miskiewicz
