Extracellular fibrillin microfibrils as multifunctional scaffolds integrating growth factor signalling in the skin (B12)

• Subject Area: Biochemistry
• Term: from 2013 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208

To understand disease pathomechanisms driven by fibrillin deficiency we want to define the molecular requirements by which fibrilin microfibrils integrate growth factor targeting, storage, and activation. Thereby we would like to delineate in which disease situations biomechanical or proteolytic processes are involved in the aberrant activation of matrix-bound growth factors and how this translates into dysregulated collagen homeostasis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 829: Molecular Mechanisms Regulating Skin Homeostasis
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Gerhard Sengle