The impact of influenza virus genome variability on host cell kinase networks and the anti-viral response (C01+)

The genomic plasticity of Influenza A viruses (IAVs) enables them to quickly adapt to new circumstances and cross species barriers, thus causing epidemics and occasional pandemics. We want to (I) further elucidate in vitro and in vivo the interaction between the host cell factor NF-kB and genetically defined IAVs and (II) identify the IAV factors/functions rendering the virus sensitive to NF-kB inhibition. Part (III) will reveal the functional relevance of IAV-regulated protein kinase signalling networks and of phosphorylations of viral proteins.

DFG Programme Collaborative Research Centres

Subproject of SFB 1021:  RNA Viruses: RNA Metabolism, Host Response and Pathogenesis

Applicant Institution Philipps-Universität Marburg

Co-Applicant Institution Justus-Liebig-Universität Gießen

Project Heads Professor Dr. Stephan Pleschka; Professor Dr. M. Lienhard Schmitz