Cellular Reorganization upon state transitions (C03)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 200049484

This project aims at identifying the molecular processes that control cellular fate transitions during normal development and differentiation, or in disease processes. For this, we construct and analyze differential gene regulatory networks that govern the observed transcriptomic alterations between two cell fate states or to study the rewiring of protein interaction networks. C3 will focus on the molecular interactions involving transcription factors, chromatin modifier proteins, or splicing factors in neurons, melanocytes and melanoma cells and in cytotoxic immune cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1027: Physical Modelling of Non-Equilibrium Processes in Biological Systems
• Applicant Institution: Universität des Saarlandes
• Project Head: Professor Dr. Volkhard Helms