Adipokines as modulators of cardiovascular function (C06)

• Subject Area: Cardiology, Angiology ; Endocrinology, Diabetology, Metabolism
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

The impact of adipokines on metabolic and cardiovascular dysfunction and their precise mode of action on the vasculature are incompletely understood. In the next phase of project C6, we aim to explore the role of chemerin and neuregulin 4 on cardiometabolic dysfunction by testing their effects on vascular function and metabolic traits in LDLR-/-;aP2-nSREBP1c-Tg mice. By focusing on the molecular mechanisms of adipokine actions on the cardiovascular system, the project now integrates local expertise in adipokine and cardiovascular disease research.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Professor Dr. Mathias Fasshauer, until 4/2020; Professor Dr. Ulrich Laufs, since 7/2021; Professorin Dr. Anke Tönjes, since 5/2020