Role of Trib1 in Obesity and Metabolism – Tissue Specific Effects and Target Molecules (B07+)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

The gene tribbles homolog-1 (Trib1) was recently identified as one of the genes related to lipid metabolism and atherosclerosis. Given the observed significant metabolic changes in white adipose tissue and skeletal muscle of Trib1-deficient mice, the projects applies conditional knockout strategies to create mice specifically lacking Trib1 in adipose tissue and skeletal muscle. Metabolic and functional characterization of these models will elucidate how Trib1-depletion ameliorates insulin sensitivity, obesity associated adipose tissue dysfunction and ectopic fat deposition in skeletal muscle.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Professor Dr. Ralph Burkhardt; Professor Dr. Joachim Thiery, until 12/2016