Mechano-sensitive adhesion GPCR in adipose tissue (B06)

• Subject Area: Biochemistry ; Gastroenterology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

We will test the hypothesis that mechano-activation of adhesion GPCRs (aGPCR) regulate adipocyte differentiation and metabolism in vivo. Thus, we will analyze i) signaling pathways modulated by distinct aGPCRs under mechanical force application, ii) the functional impact of mechano-stimulation on adipocyte function, and iii) the in vivo relevance of mechano-sensitive aGPCR in adipose tissue (AT) of mice and humans. This will be achieved using live imaging, atomic force microscopy and animal models of aGPCR deficiency. In a translational step, function-altering variants of aGPCRs in humans will then be clinically examined in the framework of this CRC and explored as potential therapeutic target in obese patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Professor Dr. Daniel Huster, until 12/2016; Professorin Dr. Ines Liebscher; Privatdozent Dr. Jürgen Schiller, until 12/2016; Professor Dr. Torsten Schöneberg