Hypothalamic deep brain stimulation as a novel experimental and therapeutic approach in the treatment of adiposity
Endocrinology, Diabetology, Metabolism
Final Report Abstract
The main outcomes of the second funding period are: 1. Unilateral high frequency deep brain stimulation of the nucleus accumbens seems feasible to modulate body weight gain in the high fat diet induced obesity model. 2. In cooperation with AG van Riesen the worldwide first deep brain stimulation system usable in mice obesity models, allowing for a continuous, wirelessly programmable and verifiable stimulation has been developed and tested. 3. Enhanced beta oscillation and a decreased beta coherence in the cortico-striatal system has been identified in diet induced obesity for the first time. 4. The enhancement of beta oscillatory activity through direct central insulin application has been demonstrated. A number of trials during the last 5 years have aimed to apply invasive and non-invasive neuromodulatory strategies in order to treat obese patients. The current approaches are largely based on theoretical assumptions and accordingly very heterogeneous in terms of targets, stimulatory settings and patient selection. The results of our work provide a methodological framework to further investigated aberrant neuronal information processing in obesity and to apply specific neuromodulatroy approaches.
Publications
- Weight Loss Partially Restores Glucose-Driven Betatrophin Response in Humans. J Clin Endocrinol Metab. 2016 Nov;101(11):4014-4020
Maurer L, Brachs S, Decker AM, Brachs M, Leupelt V, Jumpertz von Schwartzenberg R, Ernert A, Bobbert T, Krude H, Spranger J, Mai K
(See online at https://doi.org/10.1210/jc.2016-1788) - High-fat dietinduced obesity and insulin resistance are characterized by differential beta oscillatory signaling of the limbic cortico-basal ganglia loop. Scientific Reports. 2017;7(1):15555
Maurer L, Tang H, Haumesser JK, Altschüler J, Kühn AA, Spranger J, et al.
(See online at https://doi.org/10.1038/s41598-017-15872-x)
