Project Details
Neural, hormonal and behavioral mechanisms of long-term weight maintenance
Applicant
Professor Dr. John-Dylan Haynes
Subject Area
Pediatric and Adolescent Medicine
Endocrinology, Diabetology, Metabolism
Endocrinology, Diabetology, Metabolism
Term
from 2012 to 2015
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 101434729
Final Report Year
2019
Final Report Abstract
In this project, we have evaluated the link between brain activity or behavioural parameters acquired with two functional paradigms (food cue-reactivity and delay discounting) and body mass changes in (initially) obese patients assessed across a time period of 39 month. By using the functional paradigms, which are also applied in research on substance-related disorders, we have found that BMI changes are related to activity in neural networks that largely overlap in terms of spatial location and function with networks involved in substance-related disorders. This overlap suggests, that shared biological systems underlie the maintenance of the diseases. These findings can be utilized in therapeutic approaches applied to treat obesity.
Publications
- Role of neural impulse control mechanisms for dietary success in obesity. NeuroImage. 2013; 83: 669 - 678
Weygandt M, Mai K, Dommes E, Leupelt V, Hackmack K, Kahnt T, Rothemund Y, Spranger J, Haynes JD
(See online at https://doi.org/10.1016/j.neuroimage.2013.07.028) - DLPFC impulse control counteracts a yo-yo effect in post-diet weight maintenance. NeuroImage. 2015; 109: 318 – 327
Weygandt M, Mai K, Dommes E, Hackmack K, Leupelt V, Spranger J, Haynes JD
(See online at https://doi.org/10.1016/j.neuroimage.2014.12.073)