Spatio-temporal positioning of nanoagents by protein self-organization (A09)

• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 201269156

We propose to harness spatiotemporal concentration patterns emerging from protein self-organization to position functional nanoagents, such as membrane vesicles and biofunctionalized nanoparticles. We will first explore the possibility of active supramolecular cargo positioning on surfaces by a newly discovered mechanism for directed transport by the bacterial MinDE system. Furthermore, we aim to reconstitute in vitro the Magnetospirillum gryphiswaldense magnetosome transport system on filaments, based on the protein machinery MamYJK.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1032: Nanoagents for Spatio-temporal Control of Molecular and Cellular Reactions
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professorin Dr. Petra Schwille