Rhomboid proteases in ER-associated degradation
(12)
Subject Area
Biochemistry
Term
from 2012 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 201348542
TP12 investigates how the rhomboid protease RHBDL4 resolves and avoids proteotoxic stress in the Endoplasmic Reticulum (ER) and secretory pathway. By combining cell-based studies with proteomics and membrane biochemistry with cryo-electron microscopy, the Lemberg group aims to decipher the molecular mechanism of RHBDL4-catalyzed cleavage. In a second work stream, TP12 will use a combination of tissue culture models and primary cells from RHBDL4 knockout mice to study the function of RHBDL4 in integrating and regulating secretion dynamics in stress response.
DFG Programme
Collaborative Research Centres
