Stress dependent responses of mRNA 3´-end processing (05)

Subject Area Cell Biology
Term from 2012 to 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 201348542
 

Project Description

The team of Andreas Kulozik and Matthias Hentze (TP05) found that stress induces alternative polyadenylation (APA) of mRNAs. The team will address the molecular mechanism and the physiological importance of this novel mode of stress-dependent gene regulation. Using global tools for the analysis, they aim at unraveling the key cis-acting sequences and trans-acting factors involved in ribotoxic, ER- and oxidative stress-induced APA.
DFG Programme Collaborative Research Centres
Subproject of SFB 1036:  Cellular Surveillance and Damage Response
Applicant Institution Ruprecht-Karls-Universität Heidelberg
Co-Applicant Institution European Molecular Biology Laboratory (EMBL)
Project Heads Professor Dr. Matthias Hentze; Professor Andreas Eckhard Kulozik, Ph.D.