Surface contact and adhesion induced responses in yeast (E03 (C03))

• Subject Area: Cell Biology
• Term: from 2012 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192445154

In this project, we aim at understanding how in yeast adhesion to solid surfaces triggers the formation of biofilms. For this purpose, we will test the hypothesis that cell-surface adhesion triggers cell wall stress and responses that are mediated by cell wall-associated sensor proteins. Specifically, we will investigate the structural and functional diversity of (i) Flo11-type adhesins from different yeasts and of (ii) different Wsc-type mechanosensors of budding yeast with respect to contact sensing and cellular self-nonself discrimination by using complementary in vivo and in vitro experimental approaches.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 987: Microbial Diversity in Environmental Signal Response
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professor Dr. Hans-Ulrich Mösch