Project Details
Projekt
Mechanical control of protein conformations (A05)
Subject Area
Biophysics
Term
from 2012 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 201302640
In this project, we use single-molecule force spectroscopy by optical tweezers to study the conformational mechanics of the Hsp70 chaperone system and the mechanical action of chaperones on their substrate proteins. The overall goal is to understand chaperone enzymes as mechanical machines. Three subprojects will study the ATP-driven conformational changes of DnaK in dependence of its co-chaperones and substrate proteins, the chaperone mediated conformational control of steroid hormone receptors and the tumor suppressor p53.
DFG Programme
Collaborative Research Centres
Applicant Institution
Technische Universität München (TUM)
Project Head
Professor Dr. Matthias Rief
