Molecular dissection of autoimmune lesion induction and resolution in the CNS (B10)

The formation and resolution of neuroinflammatory lesions is determined by the balance of lesion-inducing signals derived from infiltrating auto-reactive T cells and lesion-resolving signals at least in part derived from CNS resident cells. Here we now want to use CRISPR gene editing screens to characterize the molecular architecture underlying these critical neuro-immune interactions and validate the disease relevance of emerging communication pathways in deeply phenotyped biosamples from MS patients.

DFG Programme CRC/Transregios

Subproject of TRR 128:  Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease

Applicant Institution Universität Münster

Project Heads Privatdozent Dr. Naoto Kawakami; Professor Dr. Martin Kerschensteiner