Molecular dissection of autoimmune lesion induction and resolution in the CNS
(B10)
Subject Area
Clinical Neurology; Neurosurgery and Neuroradiology
Term
from 2012 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703
The formation and resolution of neuroinflammatory lesions is determined by the balance of lesion-inducing signals derived from infiltrating auto-reactive T cells and lesion-resolving signals at least in part derived from CNS resident cells. Here we now want to use CRISPR gene editing screens to characterize the molecular architecture underlying these critical neuro-immune interactions and validate the disease relevance of emerging communication pathways in deeply phenotyped biosamples from MS patients.
DFG Programme
CRC/Transregios