Linking cholesterol metabolism in myeloid cells to remyelination in mice and humans (B07)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

The aim of our study is to understand how different functional states of myeloid cells are linked to oligodendrocytes and remyelination in MS lesions. We will 1. dissect the molecular mechanisms underlying impaired remyelination caused by a maladaptive immune response induced by accumulated myelin debris in myeloid cells and 2. test the hypothesis that lipidated ApoE particles formed after myelin debris clearance are reutilized by oligodendrocytes to provide cholesterol for remyelination. To address our questions we will combine our expertise in oligodendroglial and myelin biology, neuropathology, stem cell technologies and molecular biology.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Professorin Dr. Tanja Kuhlmann; Professor Dr. Mikael Jakob Simons, since 1/2021; Professorin Jacqueline Trotter, Ph.D., until 12/2020