Topological patterns of damage and compensation in chronic neuroinflammation (B05)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

Although research has made significant progress, there are still mechanistic factors that markedly influence disease progression and compensation reserve, making an accurate prognosis of subgroup and individual disease courses in MS extremely challenging. For the next funding period, we propose to elaborate the analytical framework for the automatic stratification of disease courses and therapeutic responses. Using advanced MRI together with brain networks phenotyping and immune response analyses, we aim to early recognize patients at high risk for disease progression (i.e. evolving functional impairment) or with insufficient therapeutic responses to immunomodulation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Sergiu Groppa; Professor Dr. Sven G. Meuth; Professor Dr.-Ing. Muthuraman Muthuraman, Ph.D., since 1/2021; Professorin Dr. Frauke Zipp, until 12/2020