Topological patterns of damage and compensation in chronic neuroinflammation (B05)

Although research has made significant progress, there are still mechanistic factors that markedly influence disease progression and compensation reserve, making an accurate prognosis of subgroup and individual disease courses in MS extremely challenging. For the next funding period, we propose to elaborate the analytical framework for the automatic stratification of disease courses and therapeutic responses. Using advanced MRI together with brain networks phenotyping and immune response analyses, we aim to early recognize patients at high risk for disease progression (i.e. evolving functional impairment) or with insufficient therapeutic responses to immunomodulation.

DFG Programme CRC/Transregios

Subproject of TRR 128:  Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease

Applicant Institution Universität Münster

Project Heads Professor Dr. Sergiu Groppa; Professor Dr. Sven G. Meuth; Professor Muthuraman Muthuraman, Ph.D., since 1/2021; Professorin Dr. Frauke Zipp, until 12/2020