Analysis and therapeutic modifications of innate immune regulatory networks in controlling T-cell activation in MS (A09)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

Innate immune-regulatory networks are crucial for controlling T-cell activation in MS. By combining access to unique samples with cutting edge technologies we aim to investigate immune-regulatory networks of peripheral (blood, lymph node) and CNS associated (cerebrospinal fluid) immune compartments to (i) understand alterations of these networks during disease initiation and progression in MS; (ii) identifying parameters discriminating MS from other neuroinflammatory autoimmune diseases; (iii) exploring the impact of immune-modulating therapies on these networks; and (iv) generating an MS-specific immunological roadmap in distinct compartments as a path for diagnostic, prognostic, and therapeutic signatures.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Dr. Catharina C. Groß; Professor Dr. Heinz Wiendl