Genomic instability, disease evolution and rational treatment development in CLL mouse models (B01)

• Subject Area: Hematology, Oncology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 217328187

We characterized in detail the role of telomere dysfunction in CLL pathogenesis using patient samples and murine models. Further, we deciphered mechanisms underlying PI3K and BCL2 inhibitor resistance. We now aim to comprehensively understand the cell-intrinsic genetic changes and cell-extrinsic micro-environmental factors that underlie the poorly understood phenomenon of Richter syndrome (RS), using various in vivo models, with validation of the findings on primary patient material and xenograft systems. The project will further uncover novel drug targets and combination strategies for the treatment of RS.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1074: Experimental Models and Clinical Translation in Leukemia
• Applicant Institution: Universität Ulm
• Project Heads: Dr. Billy Jebaraj, since 7/2022; Dr. Annika Müller, from 7/2020 until 6/2022; Professor Dr. Stephan Stilgenbauer, since 7/2020