In recent years, there has been enormous progress in characterizing genetic drivers in leukemogenesis, followed by the successful clinical development of molecular therapies. Collaborative Research Center (CRC) 1074 has anticipated and accompanied this development from the very beginning. CRC 1074 has aimed at bridging basic, translational and (pre)clinical research in the field of leukemia, focusing on translating insights into the pathogenesis of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL) into new therapies.The structure of CRC 1074 consists of two closely interacting Project Groups: Group A projects with the expertise in experimental models of leukemogenesis, and Group B projects focusing on translational / preclinical leukemia research. Here, CRC 1074 has the privilege to benefit from most visible clinical research in leukemia and unique biobanks of the national leukemia study groups located at Ulm University, belonging to the largest clinically and molecularly annotated collections worldwide. The individual projects are complemented by two core projects, the Bioinformatics/Single-Cell Sequencing Core (Z1) and the Mass Spectrometry and Proteomics Core (Z3). In the grant renewal proposal, seven new principal investigators have been integrated, five of them being young female scientists with an outstanding record, at different stages of their career. Furthermore, CRC 1074 has integrated two research groups from the German Cancer Research Center in Heidelberg, and one group from Charité University Medicine Berlin, based on their specific expertise and on already long-standing collaborations.We expect that a third funding period of CRC 1074 will further successfully strengthen the international visibility of basic and translational leukemia research at Ulm University and continue to provide major scientific contributions. The invaluable resources of CRC 1074 will facilitate translating research findings into clinical practice and ultimately improve care of patients with leukemia.
DFG Programme
Collaborative Research Centres
Completed projects
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A01 - The contribution of mechanisms of aging of HSCs to leukemia initiation and progression
(Project Head
Geiger, Hartmut
)
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A02 - Dissecting the role of Mixed-Lineage-Leukemia 5 (MLL5) in the DNA damage response and its potential effects on leukemogenesis
(Project Head
Fehling, Hans-Jörg
)
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A03 - Notch signaling as a novel target of AML/ETO
(Project Heads
Geiger, Hartmut
;
Oswald, Franz
)
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A04 - Dissecting of the function of the “Lymphoid enhancer-binding factor 1” (Lef1) in acute myeloid leukemia
(Project Head
Buske, Christian
)
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A05 - Characterization of regulatory and target pathways of microRNAs downstream of the leukemogeneic Hoxa9/Meis1 axis
(Project Heads
Kuchenbauer, Florian
;
Rouhi, Arefeh
)
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A06 - The role of homeobox genes in erythroid leukemia
(Project Head
Feuring-Buske, Michaela
)
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A07 - Role of EZH2 in B-lymphoid and myeloid leukemogenesis
(Project Head
Wirth, Thomas
)
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A08 - Mechanistic basis of CLL resistance to targeted tumor therapy in a pathophysiologically relevant cellular context: role of Rho GTPases and phospholipase C-y2
(Project Head
Gierschik, Peter
)
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A09 - Role of B cell receptor signaling and acquired immunoglobulin gene changes in the development of chronic lymphocytic leukemia (CLL)
(Project Heads
Hobeika, Elias
;
Jumaa, Hassan
)
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A10 - Investigating the crosstalk between pre-BCR and IL-7R signaling in B-cell precursor acute lymphoblastic leukemia
(Project Head
Jumaa, Hassan
)
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B01 - Genomic instability, disease evolution and rational treatment development in CLL mouse models
(Project Heads
Jebaraj, Billy
;
Müller, Annika
;
Stilgenbauer, Stephan
)
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B02 - Mechanisms of CLL progression and Richter transformation in patients with CLL treated with agents targeting BTK and BCL2
(Project Heads
Döhner, Hartmut
;
Mertens, Daniel
;
Stilgenbauer, Stephan
)
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B03 - Molecular and functional characterization of cooperating events in acute myeloid leukemia with NPM1 mutation
(Project Heads
Bullinger, Lars
;
Döhner, Konstanze
)
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B04 - Functional analysis of recurrent deletions of chromosomal band 3p14.1-p13 in acute myeloid leukemia
(Project Head
Gaidzik, Verena
)
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B06 - Multi-targeting and identification of synergistic activities to overcome therapy resistance in ALL
(Project Heads
Debatin, Klaus-Michael
;
Meyer, Lüder Hinrich
)
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B07 - Attenuated oncolytic measles virus against ALL of childhood: preclinical proof-of-principle and molecular mechanisms
(Project Head
Beltinger, Christian
)
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B08 - The role of deubiquitinating enzyme USP7 in the pathogenesis and treatment of acute myeloid leukemia
(Project Head
Krönke, Jan
)
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B09 - Causes and consequences of epigenetic disturbances in T-prolymphocytic leukemia
(Project Heads
Siebert, Reiner
;
Wiehle, Laura
)
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B10 - Genetic and epigenetic characterization of chronic lymphocytic leukemia with translocations involving the immunoglobulin loci
(Project Heads
Mottok, Anja
;
Siebert, Reiner
)
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B11 - Novel oncogenes in complex karyotype acute myeloid leukemia
(Project Head
Plass, Christoph
)
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B12 - Dissecting AML treatment response to FLT3 inhibitors by single-cell sequencin
(Project Heads
Döhner, Konstanze
;
Rippe, Karsten
)
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Z01 - Bioinformatics core - semantic knowledge fusion and non-standard optimization - Next Generation Sequencing core
(Project Heads
Kestler, Hans A.
;
Rippe, Karsten
)
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Z02 - Central Tasks
(Project Head
Döhner, Hartmut
)
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Z03 - Qualitative and quantitative proteomics for a comprehensive picture of protein dynamics in leukemia
(Project Head
Wiese, Sebastian
)
