The length of the poly(A) tail of maternal-effect gene mRNAs in the mammalian oocyte and egg: dynamics and possible relevance

Applicants Professorin Dr. Ursula Eichenlaub-Ritter; Professorin Dr. Ruth Grümmer; Professor Dr. Bernhard Horsthemke
Subject Area Human Genetics
Term from 2012 to 2015
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 214365266
 

Final Report

Final Report Year 2016

Final Report Abstract

The data generated in this collaborative project demonstrate that RNA storage and stability, poly(A) tail dynamics, histone methylation patterns and embryonic genome activation are not (exclusively) timed by ovulation or fertilization, but, at least partly, regulated by events in the growing or maturing oocyte. A delay in ovulation or fertilization desynchronizes oocyte development and fertilization, which may consequently affect the embryonic programs with potentially long-lasting effects.

Publications

DFG Programme Research Grants