Die Bedeutung des Hypoxia-Inducible Factors 1 alpha und reaktiver Sauerstoffspezies in Endothelzellen für die Wechselwirkung zwischen Tumorgewebe und versorgenden Gefäßen im Rahmen der Strahlentherapie
Final Report Abstract
Angiogenesis and the development of a vascular network is required during tumor progression, and involves release of proangiogenic factors, including vascular endothelial growth factor (VEGF), from both malignant and stromal cell types. By deleting VEGF tissue-specifically in myeloid cells, we determined the impact of inflammatory cell-derived VEGF on vessel density and tumor progression. Deletion of VEGF in myeloid cells attenuated the formation of a typical high-density vessel network, blocked the "angiogenic switch". Although the onset of tumor formation was not affected, these tumors showed accelerated progression to malignant stages and increased tumor masses. Our data suggest that macrophage-derived VEGF is essential for some aspects of tumor angiogenesis, although surprisingly can promote progression and a more malignant phenotype in mammary tumors.
Publications
- Nature. 2008 Dec 11 ;456(7223): 814-8
Stockmann C. et al.
- Nature. 2008 Dec 11;456(7223):809-13
Greenberg JI. et al.
