Molecular mechanisms of leukocyte activation and recruitment during systemic inflammatory responses (SIRS and sepsis)

• Applicant: Professor Dr. Alexander Zarbock
• Subject Area: Anaesthesiology
• Term: from 2011 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 211933074

• Final Report Year: 2017

Final Report Abstract

No abstract available

Publications

• Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. Journal of Experimental Medicine, Vol. 209. 2012, pp. 407-21.
  Block H., Herter J.M., Rossaint J., Stadtmann A., Kliche S., Lowell C.A., Zarbock A.
  
• The PSGL-1-Lselectin signaling complex regulates neutrophil adhesion under flow. Journal of Experimental Medicine, Vol. 210. 2013, No. 11, 2171-2180.
  Stadtmann A., Germena G., Block H., Boras M., Rossaint J., Sundd P., Lefort C., Fisher C.I., Buscher K., Gelschefarth B., Urzainqui A., Gerke V., Ley K., Zarbock A.
  
• Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial. Journal of the American Medical Association, Vol. 313. 2015, Issue 21, pp. 2133-2141.
  Zarbock A., Schmidt C., Van Aken H., et al.
  
• Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nature Communications, Vol. 7. 2016, Article number: 13464.
  Rossaint J., Kühne K., Skupski J., Van Aken H., Looney M.R., Hidalgo A., Zarbock A.
  
• FGF23 signaling impairs neutrophil recruitment and host defense during CKD. Journal of Clinical Investigation, Vol. 126. 2016, Issue 3, pp. 962-974.
  Zarbock A.
  
• Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial. Intensive Care Medicine, Vol. 43. 2017, Issue 11, pp. 1551–1561.
  Meersch M., Schmidt C., Hoffmeier A., Van Aken H., Wempe C., Gerss J., Zarbock A.
  
• Skap2 is required for β2 integrinmediated neutrophil recruitment and functions. Journal of Experimental Medicine, Vol. 214. 2017, no. 3, pp. 851-874.
  Boras M., Volmering S., Bokemeyer A., Rossaint J., Block H., Bardel B., Van Marck V., Heitplatz B., Kliche S., Reinhold A., Lowell C., Zarbock A.