Structure and function of RNP complexes targeting ncRNA to Chromatin (A04/B02)

• Subject Area: Biochemistry
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 185476941

Non-coding RNAs are regulatory molecules in the cell that in part are exerting their function bound to chromatin. We showed that the formation of triple helices is one mechanism of sequence specific targeting of RNA to chromatin and that these structures exist in vivo. We will first, address the molecular function of triple helix bound RNAs on gene regulation and chromatin structure, and second analyse the function and structure of our newly characterized triple helix binding proteins involved in rRNA gene regulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 960: Ribosome Formation: Principles of RNP Biogenesis and Control of their Function
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Gernot M. Längst