Project Details
Projekt
Organization of the synaptic active zone scaffold by Bruchpilot and RIM-binding protein (A06)
Subject Area
Biochemistry
Term
from 2011 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 184695641
Organization of the synaptic active zone scaffold by Bruchpilot and RIM-binding proteinNeurotransmission at chemical synapses depends on elaborate protein scaffolds that decorate active zones. In project A06, we aim at devising a pseudo-atomic model of the Bruchpilot/RIM-binding protein-based core of the active zone scaffold at Drosophila neuromuscular junctions. To this end, we will combine results from protein crystallography, biochemical structure probing, phylogenetic co-variation analysis, super-resolution light microscopy and cryo-electron tomography in an integrative structural modeling approach.
DFG Programme
Collaborative Research Centres
Applicant Institution
Freie Universität Berlin
Project Heads
Professor Dr. Stephan J. Sigrist; Professor Dr. Markus C. Wahl
