Regulierung der angeborenen Immunantwort durch Highdensity Lipoproteine (B11)

We aim to analyze the mechanisms by which the membrane cholesterol content can influence the activation threshold of key immune signaling receptors by (I) analyzing the consequence of cholesterol modulation on receptor signalling; (II) assessing the influence of membrane cholesterol on the assembly of myddosomes using biochemical and ultrastructural analytical tools; (III) to decipher the trans-criptome responses of receptor signaling after modulation of membrane cholesterol content; and (IV) to define the consequences of cholesterol concentration manipulation on the development of inflammation in vivo.

DFG-Verfahren Sonderforschungsbereiche

Teilprojekt zu SFB 645:  Regulation und Manipulation von biologischer Informationsübertragung in dynamischen Protein- und Lipidumgebungen

Antragstellende Institution Rheinische Friedrich-Wilhelms-Universität Bonn

Teilprojektleiter Professor Dr. Eicke Latz