Die Bedeutung von Cysteinproteasen und Cysteinproteaseinhibitoren für die Pathogenität von Entamoeba histolytica

• Applicant: Professorin Dr. Iris Bruchhaus
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2005 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 20088214

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• (2006) Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica. Mol. Biochem. Parasitol. 149, 58-64
  Tillack, M., Nowak, N., Lotter, H., Bracha, R., Mirelman, D., Tannich, E., Bruchhaus, I.
  
• (2007) Proteomic analysis of Entamoeba histolytica. Parasitol. Res. 11, 1-10
  Tolstrup, J., Krause, E., Tannich, E., Bruchhaus, I.
  
• (2007) Protozoan parasites: Programmed cell death as a mechanism of parasitism. Trends in Parasitol. 23, 376-383
  Bruchhaus, I., Roeder, T., Rennenberg, A., Heussler, V.T.
  
• (2007) Structure and content of the Entamoeba histolytica genome. Adv. Parasitol. 65, 51-190
  Clark, C.G., Alsmark, U.C.M., Hofer, M., Saito-Nakano, Y., Ali, V., Marlon, S., Weber, C., Mukherjee, C., Bruchhaus, I., Tannich, E., Leippe, M., Sicheritz-Ponten, T., Foster, P.G., Samuelson, J., Noel, C.J., Hirt, R.P., Embley, T.M., Gilchrist, C.A., Mann, B.J., Singh, U., Ackers, J.P., Bhattacharya, S., Bhattacharya, A., Lohia, A., Guillen, N., Duchene, M., Nozaki, T., Hall, N.
  
• (2007) The Entamoeba histolytica genome: primary structure and expression of proteolytic enzymes. BMC Genomics, 8,170
  Tillack, M., Biller, L., Irmer, H., Freitas, M., Gomes, M.A., Tannich, E., Bruchhaus, I.
  
• (2008) An Entamoeba cysteine peptidase specifically expressed during encystations. Parasitol. International. 57,521-524
  Ebert, F., Bachmann, A., Nakada-Tsukui, K., Hennings, I., Drescher, B., Nozaki, T., Tannich, E., Bruchhaus, I.
  
• (2009) Major cysteine peptidases of Entamoeba histolytica are required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicity. Mol. Microbiol. 72,658- 667
  Irmer, H., Tillack, M., Biller L., Handal, G., Leippe, M., Roeder, T., Tannich, E., Bruchhaus, I.