Light-responsive riboswitches and miRNA activity (A06)

• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 161793742

In the upcoming funding period we will continue our collaborative search for a riboswitch against a photoswitchable small molecule and extend our ways to regulate microRNAs with light. In particular we will focus on methods to regulate microRNAs in inner organs of living organisms such as mice but also in plants in collaboration within the CRC. On top of that we want to perfect our tools for the photoregulation of RNA hybridization and apply them to the regulation of RNA G-quadruplexes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 902: Molecular Principles of RNA-based Regulation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Alexander Heckel