Bestimmung der absoluten Konfiguration von Naturstoffen in Lösung auf Basis eines integrierten experimentellen und theoretischen Ansatzes

Antragsteller Professor Dr. Uwe Reinscheid
Fachliche Zuordnung Analytische Chemie
Förderung Förderung von 2011 bis 2017
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 44192252
 

Projektbeschreibung

The determination of the absolute configuration of natural products is still a formidable task. In this proposal an integrated approach is formulated: experimental spectroscopic data (NMR, ECD, UV-Vis, IR, VCD, optical rotation data: all easily available from literature) are doubled by DFT calculated data. A statistical evaluation will be conducted with the series of the well-known menthol diastereomers (menthol, isomenthol, neomenthol, neoisomenthol). In this way an integrated approach is established which will then be applied to partly unknown cases of current research: the flavones of Silybum marianum (L.) and the family of eupomatilones. The analysis of series of compounds allows the establishment of limits of confidence for the determination of the absolute configuration. Based on this approach not only already isolated and synthesized isomers can be differentiated, but also natural products for which samples are no longer available.
DFG-Verfahren Forschungsgruppen
Teilprojekt zu FOR 934:  Relative and absolute configurations of dissolved molecules by NMR-spectroscopy in orienting media