EXC 1010:  Munich Cluster for Systems Neurology (SyNergy)

• Subject Area: Neurosciences
• Term: from 2012 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194407705

• Final Report Year: 2019

Final Report Abstract

Munich Cluster for Systems Neurology (SyNergy) SyNergy defined Systems Neurology as a new research field where systems-level biology and systems neuroscience meet clinical neurology to generate an integrative understanding of how neurological diseases emerge from the interplay of degenerative, immune and vascular mechanisms. Highlights during the funding period, SyNergy: ● initiated disease-spanning Tandem Projects, documented in >230 high impact papers (IF>10) and an >80% increase in joint LMU/TUM publications by Cluster members. ● recruited exceptional rising-star scientists to fill gaps in its research portfolio and complement a team of Cluster PIs with comprehensive expertise in basic, pathomechanistic and clinical neurosciences (including 13 ERC grant awardees). ● was instrumental in setting up the Center for Stroke and Dementia Research (CSD), which integrates research and clinics and houses 10 SyNergy labs from both universities. ● implemented a clinician-scientists program – two alumni secured prestigious DFG Emmy- Noether fellowships and joined the Cluster as PIs. ● established new programs to educate and support young investigators from high school to post-doc level and promoted gender equality by providing mentoring, family and networking support for female researchers and parent-scientists.

Link to the final report

https://dx.doi.org/10.2314/KXP:1698240678

Publications

• A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat Struct Mol Biol. 2013 Mar 10
  Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG
  (See online at https://doi.org/10.1038/nsmb.2523)
• Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016 Jun 13
  Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M
  (See online at https://doi.org/10.1038/nn.4325)
• Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nat Commun. 2013 Jul 10;4:2125
  Pilz GA, Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J, Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M
  (See online at https://doi.org/10.1038/ncomms3125)
• Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes. Nat Protoc. 8(3):481-90 (2013)
  Romanelli E, Sorbara CD, Nikić I, Dagkalis A, Misgeld T, Kerschensteiner M
  (See online at https://doi.org/10.1038/nprot.2013.022)
• EphrinB3/EphA4-Mediated Guidance of Ascending and Descending Spinal Tracts. Neuron. 2013 Dec 18;80(6):1407-20
  Paixão S, Balijepalli A, Serradj N, Niu J, Luo W, Martin JH, Klein R
  (See online at https://doi.org/10.1016/j.neuron.2013.10.006)
• Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. Ann Neurol. 73(1):86-94 (2013)
  Buck D, Albrecht E, Aslam M, Goris A, Hauenstein N, Jochim A; International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium, Cepok S, Grummel V, Dubois B, Berthele A, Lichtner P, Gieger C, Winkelmann J, Hemmer B
  (See online at https://doi.org/10.1002/ana.23749)
• Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci. 2013 Mar 31
  Bardehle S, Krüger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I, Dimou L, Götz M
  (See online at https://doi.org/10.1038/nn.3371)
• Making waves: initiation and propagation of corticothalamic ca(2+) waves in vivo. Neuron. 2013 Mar 20;77(6):1136-50
  Stroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A
  (See online at https://doi.org/10.1016/j.neuron.2013.01.031)
• Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol. 2013 May;12(5):483-97
  Wardlaw JM, Smith C, Dichgans M
  (See online at https://doi.org/10.1016/S1474-4422(13)70060-7)
• Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog glia. Cell Stem Cell. 2013 Apr 4;12(4):426-39
  Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M
  (See online at https://doi.org/10.1016/j.stem.2013.01.019)
• Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature. 2013 May 22
  Hondele M, Stuwe T, Hassler M, Halbach F, Bowman A, Zhang ET, Nijmeijer B, Kotthoff C, Rybin V, Amlacher S, Hurt E, Ladurner AG
  (See online at https://doi.org/10.1038/nature12242)
• The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network. Cell Stem Cell. 2013 Aug 6
  Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M
  (See online at https://doi.org/10.1016/j.stem.2013.07.002)
• The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS. Science (2013) Feb 7
  Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D
  (See online at https://doi.org/10.1126/science.1232927)
• The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. Molecular cell
  Mueller-Rischart A-K, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn P-H, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Truembach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF
  (See online at https://doi.org/10.1016/j.molcel.2013.01.036)
• Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat Neurosci. 2013 Sep 1
  Viganò F, Möbius W, Götz M, Dimou L
  (See online at https://doi.org/10.1038/nn.3503)
• Trnp1 regulates expansion and folding of the Mammalian cerebral cortex by control of radial glial fate. Cell. 2013 Apr 25;153(3):535-49
  Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M
  (See online at https://doi.org/10.1016/j.cell.2013.03.027)
• A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nat Commun. 2014 Dec 16;5:5683
  Williams PR, Marincu BN, Sorbara CD, Mahler CF, Schumacher AM, Griesbeck O, Kerschensteiner M, Misgeld T
  (See online at https://doi.org/10.1038/ncomms6683)
• An assay to image neuronal microtubule dynamics in mice. Nat Commun. 2014 Sep 12;5:4827
  Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T
  (See online at https://doi.org/10.1038/ncomms5827)
• Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol. 2014 Apr 29
  Schirmer L, Srivastava R, Kalluri SR, Böttinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, Hemmer B
  (See online at https://doi.org/10.1002/ana.24168)
• FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development. Neuron. 2014 Oct 22;84(2):370-85
  Seiradake E, Del Toro D, Nagel D, Cop F, Härtl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R
  (See online at https://doi.org/10.1016/j.neuron.2014.10.008)
• IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4(+) T cells by inducing Blimp1. Nat Commun. 2014 May 6;5:3770
  Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, Korn T
  (See online at https://doi.org/10.1038/ncomms4770)
• In Vivo Targeting of Adult Neural Stem Cells in the Dentate Gyrus by a Split-Cre Approach. Stem Cell Reports. 2014 Feb 6;2(2):153-62
  Beckervordersandforth R, Deshpande A, Schäffner I, Huttner HB, Lepier A, Lie DC, Götz M
  (See online at https://doi.org/10.1016/j.stemcr.2014.01.004)
• Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1. Cell. 2014 Feb 27;156(5):975-85
  Raychaudhuri S, Loew C, Körner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU
  (See online at https://doi.org/10.1016/j.cell.2014.01.055)
• Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat Med. 2014 Apr 20
  Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T
  (See online at https://doi.org/10.1038/nm.3520)
• NMDA Receptor-Dependent Multidendrite Ca2+ Spikes Required for Hippocampal Burst Firing In Vivo. Neuron. 2014 Feb 18. pii: S0896-6273
  Grienberger C, Chen X, Konnerth A
  (See online at https://doi.org/10.1016/j.neuron.2014.01.014)
• Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Nat Commun. 2014 May 28;5:3915
  Neuner J, Ovsepian SV, Dorostkar M, Filser S, Gupta A, Michalakis S, Biel M, Herms J
  (See online at https://doi.org/10.1038/ncomms4915)
• Pervasive Axonal Transport Deficits in Multiple Sclerosis Models. Neuron. 2014 Nov 25
  Sorbara CD, Wagner NE, Ladwig A, Nikić I, Merkler D, Kleele T, Marinković P, Naumann R, Godinho L, Bareyre FM, Bishop D, Misgeld T, Kerschensteiner M
  (See online at https://doi.org/10.1016/j.neuron.2014.11.006)
• Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. 2014 Mar 18
  Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J
  (See online at https://doi.org/10.1101/gr.166751.113)
• STIM1 Controls Neuronal Ca(2+) Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior. Neuron. 2014 May 7;82(3):635-44
  Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T, Konnerth A
  (See online at https://doi.org/10.1016/j.neuron.2014.03.027)
• Targeted Resequencing and Systematic In Vivo Functional Testing Identifies Rare Variants in MEIS1 as Significant Contributors to Restless Legs Syndrome. Am J Hum Genet. 2014 Jul 3;95(1):85-95
  Schulte EC, Kousi M, Tan PL, Tilch E, Knauf F, Lichtner P, Trenkwalder C, Högl B, Frauscher B, Berger K, Fietze I, Hornyak M, Oertel WH, Bachmann CG, Zimprich A, Peters A, Gieger C, Meitinger T, Müller-Myhsok B, Katsanis N, Winkelmann J
  (See online at https://doi.org/10.1016/j.ajhg.2014.06.005)
• The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol. 2014 Jan 27
  Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R
  (See online at https://doi.org/10.1083/jcb.201305037)
• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014 Jul 2;6(243):243ra86
  Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C
  (See online at https://doi.org/10.1126/scitranslmed.3009093)
• Amyloid- PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment. Mol Psychiatry. 2015 Jun 9
  Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A
  (See online at https://doi.org/10.1038/mp.2015.74)
• ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence. Mol Cell. 2015 Sep 3;59(5):713-5
  Kozlowski M, Ladurner AG
  (See online at https://doi.org/10.1016/j.molcel.2015.08.010)
• Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science. 2015 Dec 3
  Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS
  (See online at https://doi.org/10.1126/science.aad2033)
• Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models. Nat Neurosci. 2015 Nov 9
  Busche MA, Grienberger C, Keskin AD, Song B, Neumann U, Staufenbiel M, Förstl H, Konnerth A
  (See online at https://doi.org/10.1038/nn.4163)
• Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing. Acta Neuropathol. 2015 Jun 18
  Schludi MH, May S, Grässer FA, Rentzsch K, Kremmer E, Küpper C, Klopstock T; German Consortium for Frontotemporal Lobar Degeneration; Bavarian Brain Banking Alliance, Arzberger T, Edbauer D
  (See online at https://doi.org/10.1007/s00401-015-1450-z)
• Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone. Nat Neurosci. 2015 Mar 2
  Calzolari F, Michel J, Baumgart EV, Theis F, Götz M, Ninkovic J
  (See online at https://doi.org/10.1038/nn.3963)
• Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming. Cell Stem Cell. 2015 Dec 30. pii: S1934-5909(15)00548-2
  Gascón S, Murenu E, Masserdotti G, Ortega F, Russo GL, Petrik D, Deshpande A, Heinrich C, Karow M, Robertson SP, Schroeder T, Beckers J, Irmler M, Berndt C, Angeli JP, Conrad M, Berninger B, Götz M
  (See online at https://doi.org/10.1016/j.stem.2015.12.003)
• Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET. Mol Psychiatry. 2015 Oct;20(10):1141
  Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A
  (See online at https://doi.org/10.1038/mp.2015.146)
• Neurodevelopment. Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain. Science. 2015 May 15;348(6236):789-93
  Barbosa JS, Sanchez-Gonzalez R, Di Giaimo R, Baumgart EV, Theis FJ, Götz M, Ninkovic J
  (See online at https://doi.org/10.1126/science.aaa2729)
• Pericytes are involved in the pathogenesis of CADASIL. Ann Neurol. 2015 Aug 27
  Ghosh M, Balbi M, Hellal F, Dichgans M, Lindauer U, Plesnila N
  (See online at https://doi.org/10.1002/ana.24512)
• Recessive Mutations in the α3 (VI) Collagen Gene COL6A3 Cause Early-Onset Isolated Dystonia. Am J Hum Genet. 2015 May 13
  Zech M, Lam DD, Francescatto L, Schormair B, Salminen AV, Jochim A, Wieland T, Lichtner P, Peters A, Gieger C, Lochmüller H, Strom TM, Haslinger B, Katsanis N, Winkelmann J
  (See online at https://doi.org/10.1016/j.ajhg.2015.04.010)
• Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. Brain. 2015 Dec 14
  Jürgens T, Jafari M, Kreutzfeldt M, Bahn E, Brück W, Kerschensteiner M, Merkler D
  (See online at https://doi.org/10.1093/brain/awv35)
• Rescue of long-range circuit dysfunction in Alzheimer's disease models. Nat Neurosci. 2015 Nov;18(11):1623-30
  Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, Konnerth A
  (See online at https://doi.org/10.1038/nn.4137)
• Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia. Sci Transl Med. 2015 Aug 5;7(299):299ra121
  Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A
  (See online at https://doi.org/10.1126/scitranslmed.aaa9853)
• Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes. Cell Stem Cell. 2015 Jul 2;17(1):74-88
  Masserdotti G, Gillotin S, Sutor B, Drechsel D, Irmler M, Jørgensen HF, Sass S, Theis FJ, Beckers J, Berninger B, Guillemot F, Götz M
  (See online at https://doi.org/10.1016/j.stem.2015.05.014)
• Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 2015 May 7;161(4):919-32
  Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU
  (See online at https://doi.org/10.1016/j.cell.2015.03.032)
• η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. 2015 Aug 31
  Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C
  (See online at https://doi.org/10.1038/nature14864)
• Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biol Psychiatry. 2016 Dec 26
  Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J
  (See online at https://doi.org/10.1016/j.biopsych.2016.12.023)
• CTLA-4 as immunological checkpoint in the development of multiple sclerosis. Ann Neurol. 2016 Jun 28
  Gerdes LA, Held K, Beltran E, Berking C, Prinz JC, Junker A, Tietze JK, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K, Hohlfeld R
  (See online at https://doi.org/10.1002/ana.24715)
• Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proc Natl Acad Sci U S A. 2016 Jun 20
  Brändle SM, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch W, Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K
  (See online at https://doi.org/10.1073/pnas.1522730113)
• Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Sci Transl Med. 2016 Dec 14;8(369):369ra178
  Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C; Dominantly Inherited Alzheimer Network
  (See online at https://doi.org/10.1126/scitranslmed.aag1767)
• Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. J Cell Biol. 2016 Jun 27
  Gong J, Körner R, Gaitanos L, Klein R
  (See online at https://doi.org/10.1083/jcb.201601085)
• Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature. 2016 Mar 10;531(7593):191-5
  Choe YJ, Park SH, Hassemer T, Körner R, Vincenz-Donnelly L, Hayer-Hartl M, Hartl FU
  (See online at https://doi.org/10.1038/nature16973)
• Haploinsufficiency of KMT2B, Encoding the Lysine-Specific Histone Methyltransferase 2B, Results in Early-Onset Generalized Dystonia. Am J Hum Genet. 2016 Nov 9
  Zech M, Boesch S, Maier EM, Borggraefe I, Vill K, Laccone F, Pilshofer V, Ceballos-Baumann A, Alhaddad B, Berutti R, Poewe W, Haack TB, Haslinger B, Strom TM, Winkelmann J
  (See online at https://doi.org/10.1016/j.ajhg.2016.10.010)
• In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol. 2016 Mar 6
  Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B
  (See online at https://doi.org/10.1002/ana.24630)
• Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration. Genes Dev. 2016 Oct 1;30(19):2199-2212
  Ramesh V, Bayam E, Cernilogar FM, Bonapace IM, Schulze M, Riemenschneider MJ, Schotta G, Götz M
  (See online at https://doi.org/10.1101/gad.284992.116)
• Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun. 2016 Nov 16;7:13275
  Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M
  (See online at https://doi.org/10.1038/ncomms13275)
• Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease. Acta Neuropathol. 2016 Jan 2
  Zou C, Shi Y, Ohli J, Schüller U, Dorostkar MM, Herms J
  (See online at https://doi.org/10.1007/s00401-015-1527-8)
• Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis. Brain. 2016 Aug 30
  Knier B, Schmidt P, Aly L, Buck D, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T
  (See online at https://doi.org/10.1093/brain/aww219)
• Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nat Methods. 2016 Aug 22
  Pan C, Cai R, Quacquarelli FP, Ghasemigharagoz A, Lourbopoulos A, Matryba P, Plesnila N, Dichgans M, Hellal F, Ertürk A
  (See online at https://doi.org/10.1038/nmeth.3964)
• Soluble Oligomers of PolyQ- Expanded Huntingtin Target a Multiplicity of Key Cellular Factors. Mol Cell. 2016 Aug 25. S1097-2765(16)30375-6
  Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU
  (See online at https://doi.org/10.1016/j.molcel.2016.07.022)
• TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. EMBO J. 2016 Sep 12
  Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D
  (See online at https://doi.org/10.15252/embj.201694221)
• Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. J Cell Biol. 2016 Sep 12;214(6):735-52
  Gaitanos TN, Koerner J, Klein R
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• Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2016 Nov 28
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