The role of the GP5-M Spike of the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) for virus budding and viral persistence

• Applicants: Professor Dr. Nikolaus Osterrieder; Privatdozent Dr. Michael Veit
• Subject Area: Veterinary Medical Science
• Term: from 2010 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 193516483

• Final Report Year: 2020

Final Report Abstract

No abstract available

Publications

• (2013) Co-translational processing of glycoprotein 3 from equine arteritis virus: N-glycosylation adjacent to the signal peptide prevents cleavage. J Biol Chem. 288:35396-405
  Matczuk AL, Kunec D, Veit M
  (See online at https://doi.org/10.1074/jbc.M113.505420)
• (2013) Signal Peptide Cleavage from GP5 of PRRSV: Only a Minor Subfraction of Molecules Retains the Decoy Epitope, a Presumed Molecular Cause for Viral Persistence. PLOS One 8(6):e65548
  Thaa B, Sinhadri BC, Tielesch C, Krause E, Veit M
  (See online at https://doi.org/10.1371/journal.pone.0065548)
• (2014) Membrane proteins of arterivirus particles: Structure, topology, processing and function. Virus Res. 194:16-36
  Veit M, Matczuk AK, Sinhadri BC, Krause E, Thaa B
  (See online at https://doi.org/10.1016/j.virusres.2014.09.010)
• (2017) The complex co-translational processing of glycoprotein GP5 of type 1 porcine reproductive and respiratory syndrome virus. Virus Res. 240:112-120
  Thaa B, Kaufer S, Neumann SA, Peibst B, Nauwynck H, Krause E, Veit M
  (See online at https://doi.org/10.1016/j.virusres.2017.08.004)
• (2018) Differences in signal peptide processing between GP3 glycoproteins of Arteriviridae. Virology. 517:69-76
  Zhang M, Veit M
  (See online at https://doi.org/10.1016/j.virol.2017.11.026)
• (2018) Glycoprotein 3 of Porcine Reproductive and Respiratory Syndrome Virus Exhibits an Unusual Hairpin-Like Membrane Topology. J Virol. 17;92(15): e00660-18
  Zhang M, Krabben L, Wang F, Veit M
  (See online at https://doi.org/10.1128/JVI.00660-18)