Functional organization and dynamics of PI-kinase-based modules for protein sorting at endosomal membranes (C08)

• Subject Area: Biochemistry
• Term: from 2011 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 25065445

Endosomes function in the uptake, recycling, and degradation of nutrients, receptors, and cell signaling molecules. Previously, we have characterized phosphatidylinositol (PI) 4-kinase type II-based protein modules at endosomes that differentially regulate Wnt signaling. During the forthcoming funding period we will dissect the molecular basis underlying complex formation between PI3KC2ß with Raptor and HOPS and of PI4KIIa/ß and exocyst. We will analyze how these PI kinase modules are organized in time and space, how they contribute to endolysosomal membrane homeostasis, and how they regulate cell signaling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Co-Applicant Institution: Freie Universität Berlin; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP); im Forschungsverbund Berlin e.V.
• Project Heads: Professor Volker Haucke, Ph.D.; Professor Dr. Michael Krauß, until 12/2014