Ca2+ channels in micro- and macroglial cells (A14)

Subject Area Molecular Biology and Physiology of Neurons and Glial Cells
Term from 2011 to 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 157660137
 

Project Description

We will continue our studies on Ca2+-permeable cation channels determining glial cell function by capitalizing on TRPV2, and on a putative Ca2+ channel protein “calcium channel flower domain-containing protein 1“, also dubbed “flower”, which we initially characterized together with A10 (Pattu/Rettig). TRPV2 localizes to intracellular membranes but translocates to the plasma membrane upon stimulation of cells by growth factors. Flower is predominantly localized on intracellular vesicles that, in cytotoxic T cells, move to the synapse on target cell contact. Both genes, Trpv2 and Cacfd1, are expressed in microglia. We will characterize their function in microglia in vitro and in vivo (whole organism) using ko mice as controls.
DFG Programme Collaborative Research Centres
Subproject of SFB 894:  Ca2+-Signalling: Molecular Mechanisms and Integrative Functions
Applicant Institution Universität des Saarlandes
Project Heads Dr. Andreas Beck; Professor Dr. Veit Flockerzi