Analytischer Nachweis von diabetischen Stoffwechselentgleisungen insbesondere bei forensischen Fragestellungen (Hypoglykämien im Zusammenhang mit Überdosierungen mit humanen Insulinen, synthetischen Insulinanaloga oder oralen Antidiabetika)

• Applicant: Professor Dr. Frank Mußhoff
• Subject Area: Pathology
• Term: from 2010 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 187131476

In developed countries diabetes is the seventh most common cause of death. Post mortem diagnosis of glucose metabolism disorders can be difficult and vague caused by the missing of characteristic morphological findings. These disorders happen quite often and represent a danger for example for traffic attendance. Furthermore, in many cases the forensic pathologist may not be able to demonstrate unequivocal biochemical or histological proof for hyperglycaemia or hypoglycaemia. Aim of this study is the analytical detection of diabetic metabolism disorders ante and post mortem. This implies the detection of hypoglycaemias after overdoses with human or synthetic insulins or oral antidiabetics. In addition to that, parameters for the unequivocal determination of a hyperglycaemia (ketoacidosis or hyperosmolar coma) are investigated.

• DFG Programme: Research Grants