Role of p73-directed chromatin alterations for neuroendocrine differentiation in small cell lung cancer (A10)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 109546710

The p53 family gene TP73 encodes the transactivating, tumor suppressive transcription factor TAp73 and the transrepressing, oncogenic isoform Np73. Because of genetic and epigenetic TP73 alterations, TAp73 and Np73 expression are frequently upregulated in neuroendocrine small cell lung cancer (SCLC). The project investigates the role of p73-directed chromatin changes for neuroendocrine differentiation, SCLC pathogenesis and therapy.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 81: Chromatin Changes in Differentiation and Malignancies
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professor Dr. Thorsten Stiewe