Functional analysis of the histone arginine methyltransferase PRMT6
(A03)
Subject Area
General Genetics and Functional Genome Biology
Term
from 2010 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 109546710
The Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), which contributes to opposing transcriptional effects depending on its genomic location, activation at enhancers and repression at promoters. In the next funding period we will characterize the cross-talk of H3R2me2a with enhancer marks, the binding sites and recruitment mechanisms of PRMT6 to chromatin, its target site-specific chromatin interactors and finally the in vivo function of PRMT6/H3R2me2a in neurogenesis.
DFG Programme
CRC/Transregios
