GRK 1739:  Molecular Determinants of the Cellular Radiation Response and their Potential for Response Modulation

• Subject Area: Medicine
• Term: from 2012 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 182845150

• Final Report Year: 2021

Final Report Abstract

Radiotherapy is a central treatment modality in cancer patients, but improvements are urgently needed for successful high-precision loco-regional treatments administered alone or together with other cancer therapies. It is expected that combining ionizing radiation with mechanismoptimized targeted drug-therapy will improve the therapeutic gain of radiotherapy in future cancer treatment. Such advances require profound mechanistic insight on the action of ionizing radiation in normal and tumor cells, and of its interaction with drug therapy. This central task for human health was the focus of RTG1739 (GRK1739). Since its establishment in 2012, GRK1739 has added a unique and innovative structure for training of PhD and MD students in radiation sciences with international visibility and recognition. The multidisciplinary faculty combined excellence in radiation biology, experimental and clinical (radiation) oncology, with complementary expertise from molecular biology and biomedicine with direct relevance to modern radiation research in a highly interdisciplinary fashion. This generated ample synergies in research and education to the benefit of the GRK students, the projects, and the research in the focus area biomedicine of UDE and the oncology focus of the Medical Faculty. Distinct strengths were the integration of the participating clinical departments in the West German Comprehensive Cancer Center (WTZ-CCC) and the BMBF-funded „German Cancer Consortium“, as well as the access to the West German Proton Therapy Centre Essen (WPE). The research projects covered cutting-edge topics in molecular and experimental radiation oncology research, such as DNA repair, checkpoint regulation, and cell death signaling and integration of intracellular signaling with signaling input from the environment and have substantially advanced our mechanistic understanding of molecules and pathways that determine molecular, cellular and tissue responses to ionizing radiation and thus, radiation sensitivity. The multifaceted qualification program and intense supervision allowed GRK students to develop excellent scientific skills in modern biomedicine with specialized knowledge in radiation biology and oncology and transferable professional and soft skills. Additional emphasis was placed on interdisciplinary collaboration, international networking, and early scientific independence. GRK1739 successfully trained 49 PhD and 27 MD students who are optimally prepared to guide future discoveries in the field and to translate mechanistic experimental findings in advanced concepts of (radiation) oncology in interdisciplinary teams.

Publications

• ERp57 deficiency impairs growth of colorectal cancer cells by attenuating c-Myc, PLK1 and AKT activity. Volume 227 Supplement 719, Special Issue, Meeting Abstract A 04-9
  Ocklenburg T, Neumann F, Hussmann M, Kranz P, Brockmeier U, Metzen E
  
• Inhibition of the nucleotide pool sanitizing enzyme MTH1 augments genotoxic effects of ionizing radiation and hypoxia on tumor cells. Volume 216 Supplement 707 Special Issue, SI Meeting Abstract OS02-5
  Pompsch M, Brockmeier U, Riffkin, H, Kranz P, Baumann M, Gopelt K, Classen F, Wolf A, Berglund U, Helleday T, Metzen E
  
• Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly. Accepted in Nat. Struct. Mol. Biol. Accept. Letter and Manuskript copied on CD- Rom
  van den Boom J, Kueck AF, Kravic B, Müschenborn H, Giesing M, Pan D, Kaschani F, Kaiser M, Musacchio A, Meyer H
  
• Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors. PLoS one 2011;6(5):e18253
  Knauer SK., Fetz V, Rabenstein J, Friedl S, Hofmann B, Sabiani S, Schröder E, Kunst L, Proschak E, Thines E, Kindler T, Schneider G, Marschalek R, Stauber RH, and Bier C
  (See online at https://doi.org/10.1371/journal.pone.0018253)
• Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm. PLoS one 2012;7(1):e29559
  Schröder E, Gebel L, Eremeev AA, Morgner J, Grum D, Knauer SK, Bayer P, Mueller JW
  (See online at https://doi.org/10.1371/journal.pone.0029559)
• LSD1 histone demethylase expression interferes with stress response and DNA repair in a p53-dependent manner in human neuroblastoma cell lines. ANR 2012
  Kuhfittig-Kulle S, Avermidding H, Schulte JH, Eggert A, Schramm A
  
• Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer. Transl Cancer Res 2013 May 06
  Dueva R, Iliakis G
  (See online at https://doi.org/10.3978/j.issn.2218-676X.2013.05.02)
• Ionizing radiation of esophageal carcinomas leads to alterations of the hyaluronan matrix and stroma mediated cell death of tumor cells in vitro. (2013) European Journal of Cancer, Volume 49 Supplement 2
  Schütze, A., Röck, K., Jänicke, R. U., Fischer, J. W.
  (See online at https://doi.org/10.1016/S0959-8049(13)70066-2)
• Membranaktive Alkylphosphcholine sind hypoxieaktive Krebstherapeutika. Strahlenther Onkol 190, Supplement 1: 79, 2013
  Riffkin H, Oeck S, Handrick R, Henke G, Renzelmann G, Jendrossek V
  (See online at https://doi.org/10.1007/s00066-014-0677-2)
• Molecular mechanisms of resistance to protein kinase B inhibitors of the alkylphosphocholine family. European Journal of Cancer, Volume 49 Supplement 2. September p171: A835, 2013
  Oeck S, Handrick R, Jendrossek V
  (See online at https://doi.org/10.1016/S0959-8049(13)70066-2)
• Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons. Front Physiol. 2014 Sep 2;5:331
  Beckmann N, Sharma D, Gulbins E, Becker K. A, Edelmann B
  (See online at https://doi.org/10.3389/fphys.2014.00331)
• Molecular mechanisms of the antineoplastic action of Erufosine (ErPC3) in hypoxic tumor cells. European Journal of Cancer, Volume 50, S223, A913, 2014
  Riffkin H, Oeck S, Renzelman G, Handrick R, Verena Jendrossek
  (See online at https://doi.org/10.1016/S0959-8049(14)50810-6)
• The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation, Cell Cycle. 2014; 13(6):919-27
  Riemer A, Dobrynin G, Dressler A, Bremer S, Soni A, Iliakis G, Meyer H
  (See online at https://doi.org/10.4161/cc.27779)
• Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells. Radiat. Oncol. 2014 Apr 25;9:98
  Wirsdorfer F, Cappuccini F, Niazman M, de Leve S, Westendorf AM, Ludemann L, Stuschke M, Jendrossek V
  (See online at https://doi.org/10.1186/1748-717x-9-98)
• Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells. Strahlenther Onkol 190 (Suppl 1): 59,125 2014
  Niazman M, Wirsdorfer F, Cappuccini F, de Leve S, Westendorf AM, Lüdemann L, Stuschke M, Jendrossek V
  (See online at https://doi.org/10.1007/s00066-014-0677-2)
• Whole thorax irradiation initiates a local and systemic accumulation of immunosuppressive FoxP3+ regulatory T cells. European Journal of Cancer; 50:S223 A913, 2014
  Wirsdorfer F, Niazman M, Cappuccini F, de Leve S, Westendorf AM, Lüdemann L, Stuschke M, Jendrossek V
  (See online at https://doi.org/10.1016/S0959-8049(14)50812-X)
• (2015). A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery. Angew Chem Int Ed Engl. 2015 Mar 2;54(10):2941-4
  Li M, Schlesiger S, Knauer S.K, Schmuck C
  (See online at https://doi.org/10.1002/anie.201410429)
• Covalent-Allosteric Kinase Inhibitors. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10313-6
  Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Jannin P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly S, Bauer S, van Otterlo W, Rauh D
  (See online at https://doi.org/10.1002/anie.201502142)
• Dependence of radiation-induced H2AX phosphorylation on histone methylation: evidence from the chromatin immunoprecipitation assay. Int J Radiat Biol. 2015 Apr;91(4):346-53
  Sak A, Kübler D, Bannik K, Groneberg M, Stuschke M
  (See online at https://doi.org/10.3109/09553002.2015.997895)
• Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Oncotarget. 2015 Nov 17;6(36):39247-61
  Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E
  (See online at https://doi.org/10.18632/oncotarget.5746)
• Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Oncotarget. 2015 Nov 17;6(36):39247-61
  Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E
  (See online at https://doi.org/10.18632/oncotarget.5746)
• Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Oncotarget. 2015 Nov 17;6(36):39247-61
  Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E
  (See online at https://doi.org/10.18632/oncotarget.5746)
• Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Oncotarget. 2015 Nov 17;6(36):39247-61
  Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E
  (See online at https://doi.org/10.18632/oncotarget.5746)
• Dihydroartemisinin shows similiar anti-neoplastic activity in hypoxia in apoptosis-proficient and apoptosis-deficient HCT116 cells. Strahlenther Onkol 191, Supplement 1: 79 (2015)
  Rudner J, Ritter V, Ontikatze T, Handrick R, Daniel PT, Jendrossek V
  (See online at https://doi.org/10.1007/s00066-015-0847-x)
• Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors. Oncogenesis. 2015 May 18;4(5):e148
  Klein D, Schmitz T, Verhelst V, Panic A, Schenck M, Reis H, Drab M, Sak A, Herskind C, Maier P and Jendrossek V
  (See online at https://doi.org/10.1038/oncsis.2015.9)
• miR-23-3p causes cellular senescence by targeting hyaluronan synthase2: Possible implication for skin aging. J Invest Dermatol 2015 Feb;135(2):369-377
  Röck K, Tigges J, Sass S, Schütze A, Florea A M, Fender A C, Theis F J, Krutmann J, Boege F, Fritsche E, Reifenberger G, Fischer J W
  (See online at https://doi.org/10.1038/jid.2014.422)
• Modulation of chromatin structure and its effect on radiation induced DNA damage signaling and survival. Strahlenther Onkol 2015; 191, S1, 77-78
  Bannik K, Sak A, Groneberg M, Stuschke M
  (See online at https://doi.org/10.1007/s00066-015-0847-x)
• Regulation and function of acid sphingomyelinase/ ceramide pathway in irradiation induced cell death
  Sharma D
  
• The Focinator – New open-source tool for high-throughput foci evaluation of DNA damage. Radiation Oncology. 2015 Aug 4, 10:163
  Oeck S, Malewicz NM, Hurst S, Rudner J, Jendrossek V
  (See online at https://doi.org/10.1186/s13014-015-0453-1)
• The role of protein kinase Bα (Akt1) in the cellular response to ionizing radiation. Strahlenther Onkol 191, Supplement 1: 74 (2015)
  Oeck S, Riffkin H, Madel R, Handrick R, Al-Refae K, Iliakis G, Jendrossek V
  (See online at https://doi.org/10.1007/s00066-015-0847-x)
• (2016) VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell. 2016 Oct 6;64(1):189-198
  van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H
  (See online at https://doi.org/10.1016/j.molcel.2016.08.037)
• (2016). Introduction of a tailor made anion receptor into the side chain of small peptides allows fine-tuning the thermodynamic signature of peptide- DNA binding. Org Biomol Chem. 2016 Sep 21;14(37):8800-8803
  Li M, Schlesiger S, Knauer SK, Schmuck C
  (See online at https://doi.org/10.1039/c6ob01584k)
• A role for DNA-PKcs in G2 checkpoint response and DNA end resection after exposure to ionizing radiation
  Dueva R
  
• An old flame never dies - Survivin in cancer and cellular senescence. Gerontology. 2016;62(2):173-81
  Unruhe B, Schröder E, Wünsch D, Knauer SK
  (See online at https://doi.org/10.1159/000432398)
• Chromatin regulating proteins as a target for radiation therapy of glioma cell lines. Strahlenther Onkol 2016; 192, Supplement 1: 8 (2016)
  Sak A., Kübler D., Bannik K., Groneberg M., Stuschke M.
  (See online at https://doi.org/10.1007/s00066-016-0974-z)
• Deubiquitylating USP9x regulates radiosensitivity in glioblastoma by stabilizing Mcl-1 and independently of Mcl-1. Cell Death Dis 2016
  Wolfsperger F, Hogh-Binder SA, Schnittenhelm J, Psaras T, Ritter V, Bornes L, Huber SM, Jendrossek V, Rudner J
  (See online at https://doi.org/10.1038/cddis.2015.405)
• Die Bedeutung des Hypoxie-induzierten Faktor-1α (HIF-1α) in Tumorzellen für die strahlentherapeutische Behandlung maligner Tumore
  Mersch E
  
• Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma. Oncoimmunology. 2016 Feb 18;5(5):e1131378
  Büchel G, Schulte JH, Harrison L, Batzke K; Schüller U; Hansen W, Schramm A
  (See online at https://doi.org/10.1080/2162402x.2015.1131378)
• Incorporation of a nonnatural arginine analogue into a cyclic peptide leads to formation of positively charged nanotubes capable of gene transfection. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):598- 601. PMID: 26612780
  Li M, Ehlers M, Schlesiger S, Zellermann E, Knauer S.K., Schmuck C
  (See online at https://doi.org/10.1002/anie.201508714)
• Lentivirale Hemmung der Thiol-Oxidoreduktase ERp57 erhöht die Sensitivität für ionisierende Strahlung und Chemotherapeutika in kultivierten Tumorzellen. Duisburg-Essen, 2016
  Hußmann M
  
• RHAMM splice variants confer radiosensitivity in human breast cancer cell lines. Oncotarget. 2016 Apr 19;7(16):21428-40
  Schütze A, Vogeley C, Gorges T, Twarock S, Butschan J, Babayan A, Klein D, Knauer SK, Metzen E, Müller V, Jendrossek V, Pantel K, Milde-Langosch K, Fischer JW, Röck K
  (See online at https://doi.org/10.18632/oncotarget.7258)
• RHAMM splice variants confer radiosensitivity in human breast cancer cell lines. Oncotarget. 2016 Apr 19;7(16):21428-40
  Schütze A, Vogeley C, Gorges T, Twarock S, Butschan J, Babayan A, Klein D, Knauer SK, Metzen E, Müller V, Jendrossek V, Pantel K, Milde-Langosch K, Fischer JW, Röck K
  (See online at https://doi.org/10.18632/oncotarget.7258)
• Role of radiation-induced activation of the hyaluronic acid system for cellular sensitivity to ionizing radiation
  Schütze A
  
• Sensitization to radiotherapy by inhibition of epigenetic modifiers in non-small lung cancer cell lines with loss of function mutations in SWI/SNF chromatin remodeling genes. Strahlenther Onkol 192, Supplement 1: 37 (2016)
  Zernickel, E., Sak A., Bannik K., Groneberg M., Stuschke M.
  (See online at https://doi.org/10.1007/s00066-016-0974-z)
• Sensitization to radiotherapy by inhibition of epigenetic modifiers in non-small lung cancer cell lines with loss of function mutations in SWI/SNF chromatin remodeling genes. Strahlenther Onkol 192, Supplement 1: 37 (2016)
  Zernickel E, Sak A, Bannik K, Groneberg M, Stuschke M
  (See online at https://doi.org/10.1007/s00066-016-0974-z)
• Short and long term radiation effects after ionizing radiation and its dependence on chromatin modification and repair inhibition in human lung cell lines
  Bannik K
  
• The AAA-ATPase p97 and its cofactors in regulatory degradation of substrate proteins after DNA damage or replication stress
  Dressler A
  
• (2017). Morphology-Dependent Cell Imaging by Using a Self-Assembled Diacetylene Peptide Amphiphile. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14526-14530
  Jiang H, Hu XY, Schlesiger S, Li M, Zellermann E, Knauer SK, Schmuck C
  (See online at https://doi.org/10.1002/anie.201708168)
• (2017). PDI is an essential redoxsensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017 Aug 10;8(8):e2986
  Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U
  (See online at https://doi.org/10.1038/cddis.2017.369)
• (2017). PDI is an essential redoxsensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017 Aug 10;8(8):e2986
  Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U
  (See online at https://doi.org/10.1038/cddis.2017.369)
• (2017). PDI is an essential redoxsensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017 Aug 10;8(8):e2986
  Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U
  (See online at https://doi.org/10.1038/cddis.2017.369)
• (2017). PDI is an essential redoxsensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017 Aug 10;8(8):e2986
  Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U
  (See online at https://doi.org/10.1038/cddis.2017.369)
• (2017). PDI is an essential redoxsensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017 Aug 10;8(8):e2986
  Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U
  (See online at https://doi.org/10.1038/cddis.2017.369)
• (2017). PDI is an essential redoxsensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017 Aug 10;8(8):e2986
  Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U
  (See online at https://doi.org/10.1038/cddis.2017.369)
• Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity. Sci Rep. 2017 Feb 17;7:42700
  Oeck S, Al-Refae K, Riffkin H, Wiel G, Handrick R, Klein D, Iliakis G, Jendrossek V
  (See online at https://doi.org/10.1038/srep42700)
• Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity. Sci Rep. 2017 Feb 17;7:42700
  Oeck S, Al-Refae K, Riffkin H, Wiel G, Handrick R, Klein D, Iliakis G, Jendrossek V
  (See online at https://doi.org/10.1038/srep42700)
• Defining the role of the histone acetyltransferase TIP60 in DNA damage response of glioma cell lines. Strahlenther Onkol 193, Supplement 1: 9 (2017)
  Sak A, Bannik K, Zernickel E, Groneberg M, Stuschke M
  (See online at https://doi.org/10.1007/s00066-017-1137-6)
• Defining the role of the histone acetyltransferase TIP60 in DNA damage response of glioma cell lines. Strahlenther Onkol 2017; 193, S9
  Sak A., Bannik K., Zernickel E., Groneberg M., Stuschke M.
  (See online at https://doi.org/10.1007/s00066-017-1137-6)
• Deregulated BCL-2 family proteins impact on repair of DNA double strand breaks and are targets to overcome radioresistance in lung cancer. J Cancer Res Clin Oncol. 2017 Sep;143(9):1733-1744
  Wieczorek SA, Breitenbücher F, Soni A, Paul-Konietzko K, Ziegler S, Sak A, Iliakis G, Schuler M
  (See online at https://doi.org/10.1007/s00432-017-2427-1)
• Deregulated BCL-2 family proteins impact on repair of DNA double strand breaks and are targets to overcome radioresistance in lung cancer. J Cancer Res Clin Oncol. 2017 Sep;143(9):1733-1744
  Wieczorek SA, Breitenbücher F, Soni A, Paul-Konietzko K, Ziegler S, Sak A, Iliakis G, Schuler M
  (See online at https://doi.org/10.1007/s00432-017-2427-1)
• Die Rolle der Proteinkinase B (Akt) bei der zellulären Antwort auf ionisierende Strahlung
  Oeck S
  
• Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungs. FASEB J. 2017 Jul;31(7):2869-2880
  de Leve S, Wirsdörfer F, Cappuccini F, Schütze A, Meyer AV, Röck K, Thompson LF, Fischer JW, Stuschke M, Jendrossek V
  (See online at https://doi.org/10.1096/fj.201601228r)
• Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression. Antioxid Redox Signal. 2017 Apr 10;26(11):563-582
  Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, Röck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer JW, Stuschke M, Jendrossek V
  (See online at https://doi.org/10.1089/ars.2016.6748)
• Molecular dissection of effector mechanisms of RAS- mediated resistance to anti-EGFR antibody therapy; Oncotarget. 2017 Jul 11;8(28):45898- 45917
  Kasper S, Reis H, Müller A, Phasue J, Ting S, Ziegler S, Nothdurft S, Wieczorek SA, Even A, Worm K, Pogorzelski M, Wiesweg M, Goetz M, Breitenbücher S, Meiler J, Paul A, Trarbach T, Schmid KW, Breitenbücher F, Schuler M
  (See online at https://doi.org/10.18632/oncotarget.17438)
• Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy; Oncotarget. 2017 Jul 11;8(28):45898-45917
  Kasper S, Reis H, Müller A, Phasue J, Ting S, Ziegler S, Nothdurft S, Wieczorek SA, Even A, Worm K, Pogorzelski M, Wiesweg M, Goetz M, Breitenbücher S, Meiler J, Paul A, Trarbach T, Schmid KW, Breitenbücher F, Schuler M
  (See online at https://doi.org/10.18632/oncotarget.17438)
• Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance. Sci Rep. 2017 Jan 23;7:41138
  Panic A, Ketteler J, Reis H, Sak S, Herskind C, Maier P, Rübben H, Jendrossek V, Klein D
  (See online at https://doi.org/10.1038/srep41138)
• Role of radiation-induced immune changes for normal tissue toxicity with a focus on CD73/adenosine signaling and macrophages
  de Leve S
  
• The effect of high linear energy transfer ionizing radiation on mutation and reversion events at the hypoxanthin-guanin-phosphoribosyltransferase
  Kallies M
  
• The Focinator v2-0 - Graphical Interface, Four Channels, Colocalization Analysis and Cell Phase Identification Radiat Res. 2017 Jul;188(1):114-120
  Oeck S, Malewicz NM, Hurst S, Al-Refae K, Krysztofiak A, Jendrossek V
  (See online at https://doi.org/10.1667/rr14746.1)
• The GSK461364 PLK1 inhibitor exhibits strong antitumoural activity in preclinical neuroblastoma models. Oncotarget. 2017 Jan 24;8(4):6730- 6741
  Pajtler KW, Sadowski N, Ackermann S, Althoff K, Schönbeck K, Batzke K, Schäfers S, Odersky A, Heukamp L, Astrahantseff K, Künkele A, Deubzer HE, Schramm A, Sprüssel A, Thor T, Lindner S, Eggert A, Fischer M, Schulte JH
  (See online at https://doi.org/10.18632/oncotarget.14268)
• The influence of chromatin structure on DNA double strand break repair pathway choice
  Demond M
  
• VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017 Jan 17;36(2):135-150
  Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, Lux V, Ehrmann M, Weihl CC, Meyer H
  (See online at https://doi.org/10.15252/embj.201695148)
• (2018) Formation of Twisted β-Sheet Tapes from a Self-Complementary Peptide Based on Novel Pillararene-GCP Host-Guest Interaction with Gene Transfection Properties. Chemistry. 2018 Jul 11;24(39):9754-9759
  Hu XY, Ehlers M, Wang T, Zellermann E, Mosel S, Jiang H, Ostwaldt JE, Knauer SK, Wang L, Schmuck C
  (See online at https://doi.org/10.1002/chem.201801315)
• (2018). A dipeptide with enhanced anion binding affinity enables cell uptake and protein delivery. Org Biomol Chem. 2018 Mar 28;16(13):2312-2317
  Li M, Mosel S, Knauer SK, Schmuck C
  (See online at https://doi.org/10.1039/C7OB02721D)
• (2018). From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor-Targeting Nanocarriers Based on Host-Guest Interaction between a Pillar[5]arene-Based Prodrug and a RGD-Sulfonate Guest. Small. 2018 Dec;14(52):e1803952
  Hu XY, Gao L, Mosel S, Ehlers M, Zellermann E, Jiang H, Knauer SK, Wang L, Schmuck C
  (See online at https://doi.org/10.1002/smll.201803952)
• (2018). The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia. BMC Cancer. 2018 Nov 29;18(1):1190
  Pompsch M, Vogel J, Classen F, Kranz P, Iliakis G, Riffkin H, Brockmeier U, Metzen E
  (See online at https://doi.org/10.1186/s12885-018-5095-x)
• Caveolin-1, cancer and therapy resistance. Int J Cancer. 2018 Nov 1;143(9):2092-2104
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