The cell membrane as regulatory element of transmembrane protease function
(A04)
Subject Area
Metabolism, Biochemistry and Genetics of Microorganisms
Term
from 2010 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785
The project deals with the physiologic activation mechanisms of ADAM10 and ADAM17. Transient breakdown of phospholipid asymmetry of the cellular membrane was identified as a decisive event in ADAM17 activation. Mice with a deletion of the putative phosphatidylserine-binding motif in ADAM17 were generated and will be characterized. Furthermore, a role of scramblases in ADAM17 activation will be analyzed to address whether phosphatidylserine-exposure represents a general mechanism in the control of membrane-anchored sheddases.
DFG Programme
Collaborative Research Centres
