The cell membrane as regulatory element of transmembrane protease function (A04)

Subject Area Metabolism, Biochemistry and Genetics of Microorganisms
Term from 2010 to 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785
 

Project Description

The project deals with the physiologic activation mechanisms of ADAM10 and ADAM17. Transient breakdown of phospholipid asymmetry of the cellular membrane was identified as a decisive event in ADAM17 activation. Mice with a deletion of the putative phosphatidylserine-binding motif in ADAM17 were generated and will be characterized. Furthermore, a role of scramblases in ADAM17 activation will be analyzed to address whether phosphatidylserine-exposure represents a general mechanism in the control of membrane-anchored sheddases.
DFG Programme Collaborative Research Centres
Subproject of SFB 877:  Proteolysis as a Regulatory Event in Pathophysiology
Applicant Institution Christian-Albrechts-Universität zu Kiel
Project Head Professorin Dr. Karina Reiss