Entwicklung von Pd-katalysierten Domino-Reaktionen zur Synthese von molekularen Schaltern und Naturstoffen vom Lignan-Typ des Linoxepins

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Projektbezogene Publikationen (Auswahl)

• In-vitro and in-vivo activity of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, Vol. 54. 2010, Issue 1, pp. 517-521.
  L.L. Bajohr, L. Ma, C. Platte, O. Liesenfeld, L.F. Tietze, U. Groß, W. Bohne
  
• Synthesis of Novel 1-Hydroxyquinolones with High Anti-Toxoplasma Activity. Heterocycles, Special issue, Vol 82. 2010, No. 1, pp. 377 - 396.
  L.F. Tietze, L. Ma
  
• Spectroscopically Well-Characterized RGD Optical Probe as a Prerequisite for Lifetime-Gated Tumor Imaging. Molecular Imaging, Vol. 10. 2011, issue: 6, pp. 469-480.
  J.E. Mathejczyk, J. Pauli, C. Dullin, J. Napp, L.F. Tietze, H. Kessler, U. Resch-Genger, F. Alves
  
• Synthesis and Biological Evaluation of Prodrugs Based on the Natural Antibiotic Duocarmycin for Use in ADEPT and PMT. Chemistry — A European Journal, Vol. 17. 2011, Issue 6, pp. 1922-1929.
  L.F. Tietze, K. Schmuck, H.J. Schuster, M. Müller, I. Schuberth
  
• Approaches Targeting KV10.1 Open a Novel Window for Cancer Diagnosis and Therapy. Current Medicinal Chemistry, Vol. 19. 2012, Issue 5, pp. 675 - 682.
  L.A. Pardo, D. Gomez-Varela, F. Major, K. Sansuk, R. Leurs, B.R. Downie, L.F. Tietze, W. Stühmer
  
• Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products. In: J. Cossy, S. Arseniyadis (Ed.), Modern Tools for the Synthesis of Complex Bioactive Molecules. John Wiley & Sons, 2012, p. 271-334, ISBN-13: 978-0470616185.
  L.F. Tietze, S.G. Stewart, A. Düfert
  
• Photoactivatable Prodrugs of Highly Potent Duocarmycin Analogues for a Selective Cancer Therapy. Chemistry — A European Journal, Vol. 19. 2013, Issue 5, pp. 1726-1731.
  L.F. Tietze, M. Müller, S.-C. Duefert, K. Schmuck, I. Schuberth
  
• Selective Cancer Therapy by Extracellular Activation of a Highly Potent Glycosidic Duocarmycin Analogue. Molecular Pharmaceutics, Vol. 10. 2013, Issue 5, pp. 1773–1782.
  K.-C. Chen, K. Schmuck, L.F. Tietze, S.R. Roffler
  
• Enantioselective Total Synthesis of the Lignan (+)-Linoxepin. Chemistry — A European Journal, Vol. 20. 2014, Issue 51, pp. 17119-17124.
  L.F. Tietze, J. Clerc, S. Biller, S.-C. Duefert, M. Bischoff
  
• The Paecilin Puzzle - Enantioselective Synthesis of the Proposed Structures of Paecilin A and B. Heterocycles, Vol 88. 2014, No. 2, pp. 1101 - 1119.
  L.F. Tietze, L. Ma, S. Jackenkroll, J.R. Reiner, J. Hierold, B. Gnanaprakasam, S. Heidemann
  
• An efficient Domino Sonogashira/double Carbopalladation/C-H-Activation Reaction leading to Fluorescent Polycyclic Aromatic Hydrocarbons. Heterocycles Vol 90. 2015, No. 2, pp. 919 - 927.
  L.F. Tietze, C. Eichhorst
  
• Vier‐ und sechsfache Tandem‐Dominoreaktionen zur Synthese von dimeren tetrasubstituierten Alkenen als molekulare Doppelschalter. Angewandte Chemie, Vol. 127. 2015, Issue 35, pp. 10457-10461.
  L. F. Tietze, B. Waldecker, D. Ganapathy, C. Eichhorst, T. Lenzer, K. Oum, S. O. Reichmann, D. Stalke