Visualisation of herpes virus infections and immune responses as well as their modulation (B01)

• Subject Area: Immunology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 158989968

The aim of the project B1 is to better understand interactions between immune cells and virus-infected cells and how infected cells get killed in vivo. In the last funding period we investigated the killing capacities of CD8+ T cells and NK cells in lymph nodes and skin and compared the viral tropism of MCMV proficient and deficient for MCK-2 in lungs of neonatal mice. In the next funding period, we aim to understand the heterogeneity and cooperativity of cytotoxic CD8+ T cells as well as NK cells in killing virus-infected cells. Furthermore we aim to decipher the role of myeloid cells in creating an environment around infected cells that contributes control virus-spread to neighboring cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 900: Chronic Infections: Microbial Persistence and its Control
• Major Instrumentation: Flow Cytometer ; Spektral Durchflußzytometer
• Instrumentation Group: 3500 Zellzähl- und Klassiergeräte (außer Blutanalyse), Koloniezähler
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Professor Dr. Reinhold Förster; Professor Dr. Martin Messerle