Project Details
Projekt
Molecular and cellular control of the Drosophila male stem cell niche (B02)
Subject Area
Cell Biology
Term
from 2010 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 122491522
B02 will elucidate the molecular basis of the interplay between germline stem cells (GSCs) and their support cells under homeostatic and compromised cellular conditions and in collaboration with project A14 will uncover the role of mitotic checkpoint components (MCCs) in monitoring asymmetric stem cell division using the Drosophila testis as a model. The proposed work plan is based on our findings that loss of V-ATPase function in support cells causes non-cell autonomous proliferation defects in the testis germline, that depletion of nucleoporins impacts on stem cell fitness leading to their elimination and that interference with the MCC component Bub3 results in centrosome positioning defects without arresting germline stem cell division indicative for a disengaged checkpoint surveiling centrosome orientation.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Head
Professorin Dr. Ingrid Lohmann
