Interactions of signaling pathways during intestinal stem cell self-renewal and differentiation (A06)

• Subject Area: Cell Biology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 122491522

During homeostasis, the proliferation and differentiation of intestinal stem cells (ISC) in the Drosophila intestine is tightly controlled. In the past years, several conserved signaling pathways have been impli-cated in the regulation of ISCs, including the Wnt, Notch, Hedgehog, Hippo and Dpp/BMP pathways. Stress responses, infections or inflammation can lead to deregulation of stem cell proliferation, result-ing in defects in the gut epithelium. In the next funding period of the SFB873, (i) we will analyze how different signaling pathways intersect to control maintenance of the epithelium, (ii) study how they im-pact transcriptional programs in ISCs and progenitor cells and (iii) dissect how pathways interact with the intestinal microbiome during homeostasis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 873: Maintenance and Differentiation of Stem Cells in Development und Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Michael Boutros