Characterization and identification of osteoporotic animal models
((18) T01)
Subject Area
Orthopaedics, Traumatology, Reconstructive Surgery
Term
from 2010 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 107540325
The aim of T1 is to provide comprehensive understanding of osteoporosis - caused changes to the skeletal system. Therefore, osteoporosis in male rats will be induced to characterize its effect as a complimentary to previously characterized female animal models. Furthermore, T1 shall generate knockout rat models of Lipoprotein receptor Type 5/6 and Cadherin to understand their role in achieving osteoporotic bone phenotype reciprocal to the earlier generated Sclerostin and Dickkopf-1 transgenic rats. T1 shall further improve sample processing methodology to reduce numbers of experimental animals, enhance sample quality and imaging to increase sample availability for the collaborative subprojects.
DFG Programme
CRC/Transregios
